giant cell tumors (gct) are benign tumors with potential for aggressive behavior and capacity to metastasize. although rarely lethal, benign bone tumors may be associated with a substantial disturbance of the local bony architecture that can be particularly troublesome in peri-articular locations. its histogenesis remains unclear. it is characterized by a proliferation of mononuclear stromal ce...

background: giant cell tumor is a benign but locally aggressive bone neoplasm which uncommonly involves the skull. giant cell tumor (gct) of the sphenoid bone is relatively rare. in this report, we describe a tumor of the greater wing of left sphenoid bone. case presentation: a 31-year-old female was presented with headache, proptosis and diplopia of her left eye. cranial magnetic resonance ima...

Background: Giant cell tumor is a benign but locally aggressive bone neoplasm which uncommonly involves the skull. Giant cell tumor (GCT) of the sphenoid bone is relatively rare. In this report, we describe a tumor of the greater wing of left sphenoid bone. Case presentation: A 31-year-old female was presented with headache, proptosis and diplopia of her left eye. Cranial magnetic resonance ima...

we report occurrence of a rare case of giant cell tumor (gct), in a 28-year old woman, arising from anterior arc of right 6 th rib during pregnancy. it progressed rapidly during breast-feeding period, mimicking malignant bone tumor at delayed presentation.

  Giant Cell tumors (GCT) are benign tumors with potential for aggressive behavior and capacity to metastasize. Although rarely lethal, benign bone tumors may be associated with a substantial disturbance of the local bony architecture that can be particularly troublesome in peri-articular locations. Its histogenesis remains unclear. It is characterized by a proliferation of mononuclear stromal ...

Recent studies suggest that Denosumab reduces tumor size, therefore, makes the surgery easier with lowermorbidity. However, some studies have reported several complications for this drug. So, this systematic reviewwas performed to determine the effectiveness and safety of Denosumab in reducing bone destructions activity ofgiant cell tumor and skeletal-related events (SRE) in affected patients w...

abstract: objective: giant cell tumor of soft parts is a rare neoplasm that mainly affects adulst and the elderly and is usually located in the extremities. here we report a child with giant cell tumor of soft tissue, which is a very rare condition in childhood. clinical presentation: a 5 year old girl presented with a 5 month history of left lower extremity pain. she had developed paraplegia b...

The malignant transformation of conventional giant cell tumor of bone (GCTOB) is rare and usually occurs with irradiation. Here we report two neglected cases of conventional GCTOB with spontaneous malignant transformation at 11 and 16 years after initial diagnosis. In the former case, the patient refused to receive any treatment following the incisional biopsy, and in the latter, the firs...

Giant cell tumor (GCT) is a benign primary bone neoplasm that usually occurre in the long bones. The skull is affected in only 1% of cases, predominantly in the sphenoid and temporal bones. Maxillary sinus involvement is exceedingly rare. The case is a 26 year-old man presented with history of gradually increasing swelling in the right side of face without any history of trauma or systemic diso...